Studies on Pharmacodynamic Drug Interactions Between Sitagliptin and Emtricitabine in Normal and Diabetic Rats
نویسنده
چکیده
International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net © Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 77 Lakshmi Rao. T*1, Annapurna. A2, Uma Rani. G3 1,3RBVRR Women’s college of pharmacy, Affiliated to Osmania university, Hyderabad, Telangana, India. 2AU college of pharmaceutical sciences, Andhra university, Visakhapatnam, Andhra Pradesh, India. *Corresponding author’s E-mail: [email protected]
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Drug-Drug Interactions: Influence of verapamil on the pharmacokinetics of sitagliptin in rats and Ex vivo models
P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) play a significant role in the disposition and elimination of drugs. The objective of this study was to investigate the mechanism underlying the interaction between sitagliptin (substrate of P-gp and CYP3A4) and verapamil (known modulator of P-gp and CYP3A4) using in vivo, ex vivo and in situ models. Rats were treated with sitagliptin (10 m...
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